RESUMO
This study reported a case of rhinosinusitis for Respiratory Syncytial Virus in Intensive Care Unit patient. The settings were Intensive Care Unit at Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil. One female HIV-infected patient with respiratory failure and circulatory shock due to splenic and renal abscesses, who developed rhinosinusitis caused by RSV and bacteria. Respiratory viruses can play a pathogenic role in airways infection allowing secondary bacterial overgrowth.
Assuntos
Adulto , Feminino , Humanos , Infecção Hospitalar/virologia , Infecções por Vírus Respiratório Sincicial/diagnóstico , Rinite/virologia , Sinusite/virologia , Doença Aguda , Evolução Fatal , Unidades de Terapia Intensiva , Rinite/diagnóstico , Sinusite/diagnósticoRESUMO
To investigate any association between cytomegalovirus glycoprotein B (CMV gB) subtypes and central nervous system (CNS) disease in AIDS patients, proportions of different gB genotypes detected in AIDS patients with CNS disease were compared with the gB genotypes detected in AIDS patients with no neurological disorder. The patients were matched by CD4+ cell counts. CMV was detected by PCR in cerebrospinal fluid (CSF) samples obtained from AIDS patients with CNS disease and from urine and saliva samples obtained from AIDS patients without CNS disease. CMV strains obtained were digested by restriction enzymes HinffI and RsaI to classify the genotypes. The CMV gB genotype was determined in 26 CSF samples. Of these, 11/26 (42.3 por cento) typed as gB group 1, seven (26.9 por cento) as gB2, four (15.4 por cento) as gB3, and four (15.4 por cento) as gB4. The CMV gB genotype frequency distribution in the 42 AIDS patients without CNS disease showed that 18/42 (42.8 por cento) were classified as gB group 1, 10 (23.8 por cento) as gB2, seven (16.6 por cento) as gB3, and seven (16.6 por cento) as gB4. In the present study, no association was found between CMV gB genotypes and CMV-related central nervous system disease
Assuntos
Humanos , Infecções Oportunistas Relacionadas com a AIDS/fisiopatologia , Infecções Oportunistas Relacionadas com a AIDS/virologia , Infecções do Sistema Nervoso Central/fisiopatologia , Infecções do Sistema Nervoso Central/virologia , Citomegalovirus/classificação , Citomegalovirus/genética , Citomegalovirus/isolamento & purificação , Citomegalovirus/patogenicidade , DNA Viral/líquido cefalorraquidiano , Genótipo , Infecções por HIV/complicações , Infecções por HIV/virologia , Reação em Cadeia da Polimerase , Proteínas do Envelope Viral/genéticaRESUMO
To investigate any association between cytomegalovirus glycoprotein B (CMV gB) subtypes and central nervous system (CNS) disease in AIDS patients, proportions of different gB genotypes detected in AIDS patients with CNS disease were compared with the gB genotypes detected in AIDS patients with no neurological disorder. The patients were matched by CD4+ cell counts. CMV was detected by PCR in cerebrospinal fluid (CSF) samples obtained from AIDS patients with CNS disease and from urine and saliva samples obtained from AIDS patients without CNS disease. CMV strains obtained were digested by restriction enzymes HinffI and RsaI to classify the genotypes. The CMV gB genotype was determined in 26 CSF samples. Of these, 11/26 (42.3 por cento) typed as gB group 1, seven (26.9 por cento) as gB2, four (15.4 por cento) as gB3, and four (15.4 por cento) as gB4. The CMV gB genotype frequency distribution in the 42 AIDS patients without CNS disease showed that 18/42 (42.8 por cento) were classified as gB group 1, 10 (23.8 por cento) as gB2, seven (16.6 por cento) as gB3, and seven (16.6 por cento) as gB4. In the present study, no association was found between CMV gB genotypes and CMV-related central nervous system disease
